Stroke patients experience impaired voluntary movement, which impact dynamic balance, gait speed and gait ability. The current study was designed to determine the best neurorehabilitation method to improve clinical outcomes, including the time up and go test (TUG), 10 meter walking test (10MWT), and functional ambulation category (FAC) in sub-acute stroke hemiplegic patients. Forty-seven sub-acute stroke survivors consistently underwent proprioceptive whole body vibration (PWBV) or neurodevelopmental treatment (NDT) for 30 min/session, 5 days a week for 4 weeks. The PWBV platform was operated for 30 minutes at a frequency of 20 Hz. Three clinical outcome variables–the TUG, 10MWT and FAC– were examined pre- and post-intervention. We observed significant differences in the TUG, 10MWT as well as FAC scores between the PWBV and NDT groups. PWBV and NDT showed significant improvements in TUG, 10MWT and FAC. Collectively, our research provides the first clinical evidence of optimal neurorehabilitation in sub-acute stroke patients.