The aim of this study was to investigate the effects of Lee Silverman Voice Treatment Big (LSVT-BIG) exercise on balance, gait, and depression in patients with Parkinson's disease. Twenty individuals with Parkinson's disease were recruited, and divided into either the experimental group (EG) of control group (CG), 10 each. LSVT BIG exercise group (EG) and general exercise (CG) were applied 4 times a week for 30 minutes for 4 weeks, respectively. To measure balance function, the Burg balance scale (BBS) and functional reach test (FRT) were performed, and the timed up and go test (TUG), 10 meter walk test (10MWT) were performed to measure gait function. In addition, the state-anxiety test (status test: STAI-S, anxiety test: STAI-T) and Beck depression inventory (BDI) were used to evaluate depression. All tests were measured before and after the intervention. Within-group comparison in the EG showed significant improvement in all variables (p<.05). In the CG, BBS, FRT, TUG, and STAI-T tests were not significantly improved (p>0.05) and 10MWT, STAI-S, and BDI were significantly improved (p<.05). In the between- group comparison, the EG showed significantly greater improvement than the CG in all variables (p<.05). The LSVT BIG exercise may be more beneficial than general exercise to improve balance, gait, and depression in patients with Parkinson's disease.